High Throughput Sciences (HTS) offers automation and screening capabilities to MIT researchers and external collaborators. Equipped with environmentally-controlled high-content microscopes, automated liquid handlers, plate washers and readers, and robotic platforms, HTS aims to accelerate experiments from small-scale assays to large screening campaigns.
The lab provides BL2 and BL2+ spaces and conducts assay development and chemical/genetic screening using cell-free systems, cell lines, or freshly collected clinical samples. Available screening methods include cell-based and biochemical assays, high-content fluorescence or label-free imaging, pooled lentiviral libraries, and multiplexed deep sequencing.
Consultation (grant writing, sample preparation, liquid handling, engineering, data analysis, and cross-core pipelines) and training in lab automation is provided. The HTS team also engages in technology-focused research and development projects with collaborators, such as developing novel cell models, assays, and devices.
Access is available to all members of the MIT community, to the extent permitted by available capacity. Priority access is given to KI members and NCI-funded research projects. In special circumstances, access may be available to non-MIT users (details available on request from the Core Scientific Director).
The High Throughput Sciences Core is supported in part by funding provided to the Koch Institute from a National Cancer Institute Cancer Center Support Grant.
